Landmark Study Unlocks Stem Cell, DNA Secrets to Speed Therapies

Keywords FLORIDA STATE UNIVERSITY, FSU, DAVID GILBERT, GILBERT, STEM CELL, DNA, SPEED THERAPY, BIOLOGY, MOLECULAR BIOLOGY, EMBRYONIC STEM CELLS, DIFFERENTIATION Description In a groundbreaking study led by an eminent molecular biologist at Florida State University, researchers have discovered that as embryonic stem cells turn into different cell types, there are dramatic corresponding changes to the order in which DNA is replicated and reorganized. In mammalian nuclei, replication takes place at punctate sites or foci. Early-replicating foci localize to the interior of the nucleus (green), while the periphery of the nucleus and nucleoli harbor late replicating foci (red). Cytogenetic studies suggest very stable organization of the DNA within these labeled sites, but the molecular boundaries separating differentially... [read full story]