People with schizophrenia have roughly the same rate of copy number variations as do healthy controls, according to a study in the Chinese Han population published in Molecular Psychiatry 1. The results directly contradict those from a high-profile study earlier this year showing that copy number variations — deletions or duplications of chunks of DNA — occur three times more often in people with schizophrenia compared with controls2. “Inconsistent results often happen in genetic association studies,” says Yongyong Shi, lead investigator and an associate professor at Shanghai Jiao Tong University’s Bio-X Center. Shi’s team analyzed CNVs in 155 people with schizophrenia and 187 healthy controls, and found that about 14 percent of individuals with schizophrenia and 17 percent of the controls have rare CNVs — a statistically...
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