Ser1369Ala variant in sulphonylurea receptor gene ABCC8 is associated with antidiabetic efficacy...

Anhui Biomedical Institute, Anhui Medical University, Hefei, China. Objective- To investigate if genetic variants could influence antidiabetic efficacy of gliclazide in type 2 diabetes (T2D) patients. Research design and methods- 1268 T2D patients, who were diagnosed within the past 5 years and had no recent hypoglycemic treatment, were enrolled from 23 hospitals in China. All the patients were treated with gliclazide for 8 weeks. Fasting and OGTT 2 hour plasma glucose (PG), fasting insulin, and HbA1c were measured at baseline and after 8 weeks of treatment. We used two independent cohorts to test the associations of 25 single nuclear polymorphisms (SNP) in11 candidate genes with antidiabetic efficacyof gliclazide. General linear regression model was performed to test the association with adjustment for important covariates.... [read full story]