Gastroenterology and Liver Unit at the Royal Hallamshire Hospital, Sheffield, England. BACKGROUND & AIMS: Colonoscopy with mucosal biopsy is currently considered the criterion standard for the assessment of disease activity and extent in patients with ulcerative colitis. Using confocal endomicroscopy, we propose a novel in vivo optical classification using combined surface cellular resolution and deep vascular architecture crypt imaging. The aim of this study was to evaluate the efficacy of live cellular endomicroscopic imaging for the in vivo diagnosis of disease extent and activity in patients with ulcerative colitis. METHODS: The study design was a biphasic colonoscopy protocol (conventional white light vs endomicroscopy-guided biopsies). Disease activity and extent were documented initially using conventional endoscopy...
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