Mapping the progression of progranulin-associated frontotemporal lobar degeneration.

JD Rohrer is a Clinical Research Fellow, JD Warren is a Consultant Neurologist, J Barnes is a Senior Research Fellow, T Pepple is a Clinical Trials Analyst, R Boyes is a Research Fellow, R Omar is a Clinical Research Fellow, EK Warrington is Emeritus Professor of Neuropsychology, MN Rossor is a Professor of Clinical Neurology and Director, and NC Fox is a Professor of Clinical Neurology, at the Dementia Research Centre, Institute of Neurology, University College London, London, UK. Background A 55-year-old woman was followed over a 13-year period as part of a longitudinal study of people at risk for familial dementia. She was a member of a family with an autosomal dominant familial dementia that fulfilled consensus criteria for frontotemporal lobar degeneration. The patient was initially asymptomatic but developed progressive... [read full story]