Fourth International Consultation On Incontinence (ICI) - Pathophysiology Committee Highlights

PARIS, FRANCE (UroToday.com) - Dr. Koelbl began the last presentation of the morning session by discussing the various etiologies for detrusor overactivity (neurogenic vs. non-neurogenic) and how different mechanisms are responsible. Neurogenic DO is generally understood to be caused by decreased inhibitory input from the spinal cord or higher centers. Non-neurogenic DO has multiple etiologies including outlet obstruction, aging, pelvic floor disorders and others, all of which may involve different mechanisms. With respect to outlet obstruction, there is a significant amount of animal data regarding the changes induced by obstruction, which include; partial denervation which leads to hypersensitivity to neurotransmitters, reorganization of the C-fiber mediated spinal micturition reflex and changes in the detrusor muscle and... [read full story]