Molecular Imaging of Murine Intestinal Inflammation with 2-Deoxy-2-[(18)F]Fluoro-d-Glucose and...

biowizard.com     Jul 23, 2008          

Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles. BACKGROUND & AIMS: Noninvasive quantitation of mucosal immune activity is an unmet need in basic research that may be of benefit in the clinical assessment of inflammatory intestinal diseases. 2-Deoxy-2-[(18)F]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET), a measure of glucose transporter activity, has been used to detect mucosal inflammation. However, there is limited understanding of the biologic basis of mucosal FDG uptake. METHODS: A contrast-based computed tomographic isocontour method was developed to identify intestinal anatomic regions, and FDG uptake was integrated over these regions by standard uptake value and injected dose per gram to achieve reproducible quantification during longitudinal... [read full story]                    


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