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Topamax Linked to Cleft Palate, Other Birth Defects

Date Published: Tuesday, July 22nd, 2008 A new study has found evidence that children born to epileptic women taking Topamax might be at a higher risk of developing birth defect. Though the study, published this month in the journal “Neurology”, looked only at epilepsy patients taking Topamax, the findings may have serious implications for the millions of women of childbearing age who take the drug for migraine prevention. Topamax, made by Ortho-McNeil Neurologics, a division of Johnson & Johnson, was originally approved to treat epilepsy in adults and children. In 2004, the approved uses of Topamax were expanded to include the prevention of migraine headaches. Generic versions of Topamax were approved by the Food & Drug Administration (FDA) in 2006. Topamax is also used off-label to treat bipolar disorder. The study in... [read full story]                    

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