GUMC discovery highlights new direction for drug discovery

Researchers did what others thought was not possible by finding a small molecule to stop 'slippery' protein from binding to another, causing Ewing's Sarcoma Washington, DC - In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults. In the paper published online July 5 in Nature Medicine, they report discovering and successfully testing a small molecule that keeps the fusion protein from sticking to another protein that is critical for tumor formation. The researchers say this interaction is unique - and is especially surprising since the Ewing's sarcoma fusion protein is extremely flexible, which allows it to... [read full story]                    

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