ScienceDaily (July 5, 2009) — In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults. In the paper published online July 5 in Nature Medicine, they report discovering and successfully testing a small molecule that keeps the fusion protein from sticking to another protein that is critical for tumor formation. The researchers say this interaction is unique – and is especially surprising since the Ewing's sarcoma fusion protein is extremely flexible, which allows it to change shape constantly. "Most targeted small molecule cancer drugs inhibit the intrinsic activity of a single protein, but our agent stops two...
[read full story]
powered by 