Jul 5, 2009
Story Timeline: 126 days
Researchers did what others thought was not possible by finding a small molecule to stop 'slippery' protein from binding to another, causing Ewing's Sarcoma Washington, DC – In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults. In the paper published online July 5 in Nature Medicine, they report discovering and successfully testing a small molecule that keeps the fusion protein from sticking to another protein that is critical for tumor formation. The researchers say this interaction is unique – and is especially surprising since the Ewing's sarcoma fusion protein is extremely flexible, which allows it to...
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