Full Coverage

GUMC discovery highlights new direction for drug discovery

Jul 5, 2009
 
Story Timeline:  126 days

Researchers did what others thought was not possible by finding a small molecule to stop 'slippery' protein from binding to another, causing Ewing's Sarcoma Washington, DC – In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults. In the paper published online July 5 in Nature Medicine, they report discovering and successfully testing a small molecule that keeps the fusion protein from sticking to another protein that is critical for tumor formation. The researchers say this interaction is unique – and is especially surprising since the Ewing's sarcoma fusion protein is extremely flexible, which allows it to... [read full story]                    

powered by
Add Comment
Latest article on this story:

GUMC discovery highlights new direction for drug discovery

brightsurf.com Jul 6, 2009
First article on this story:

Discovery Highlights New Direction For Drug Discovery

sciencedaily.com Jul 5, 2009
Selected publications with coverage of this story:
RELATED