How Does CO2 Insufflation Pressure Affect Proliferation And Improve Apoptosis?

Main Category: Cancer / Oncology
Also Included In: GastroIntestinal / Gastroenterology;  Biology / Biochemistry
Article Date: 22 May 2008 - 0:00 PDT

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Under 10 mmHg CO2 pressure, there were no obvious effects on MKN-45 cells' proliferation and apoptosis. At 15 mmHg CO2 insufflation pressure, cells proliferation was inhibited and apoptosis improved. It may be that CO2 gas affected the growth of gastric cancer cells.

This study was performed by a team led by Professor Pei-Wu Yu. The research article is published in the World Journal of Gastroenterology.

There is an ongoing debate on the deleterious effects of CO2 on tumor cell behavior. Some authors showed an increase in cell proliferation and tumor growth and others found beneficial effects of CO2 exposition in vitro and in animal studies.

In the view of the authors, the extracellular pH differed significantly during CO2 versus helium exposure and it decreased very sharply with the insufflated pressure. The extracellular and intracellular pH was an important regulator of cell functions, such as ATP production, cell cycle, intracellular signaling and apoptosis. It is likely that all these changes influence the favorability of tumor-cell implantation at the time of laparoscopic surgery.

The role of peritoneal microenvironment in tumor-cell growth awaits further studies and looks for the safest approach to laparoscopic oncologic surgery.

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Article adapted by Medical News Today from original press release.
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Reference: Hao YX, Zhong H, Zhang C, Zeng DZ, Shi Y, Tang B, Yu PW. Effects of simulated carbon dioxide and helium pneumoperitoneum on gastric cancer cells' proliferation and apoptosis. World J Gastroenterol 2008; 14(14): 2241-2245 http://www.wjgnet.com/1007-9327/14/2241.asp

Correspondence to: Pei-Wu Yu, Professor, Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, Gaotanyan Street, Shapingba district, Chongqing 400038, China.

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection for providing a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. The WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

About The WJG Press

The WJG Press mainly publishes World Journal of Gastroenterology.

Source: Jing Zhu
World Journal of Gastroenterology