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In 1857 Dr. Elizabeth Blackwell, the first woman physician, founded the New York Infirmary for Indigent Women and Children.

New York State is an agricultural leader, ranking within the top five states for a number of products including dairy, apples, cherries, cabbage, potatoes, onions, maple syrup and many other products. The state has about a quarter of its land in farms and produced 3.4 billion dollars in agricultural products in 2001.

The city's strong entrepreneurial spirit discouraged family connections that would have stifled innovation and economic ambition. The city's cosmopolitan attitude and tolerance of many different cultures encouraged many different types of immigrant groups to settle in the city, especially German immigrants and Irish immigrants who began arriving in the late 1840s.

Three of Suffolk County's ten townships - Brookhaven, Riverhead, and Southampton - are host to the 102,500 acre (415 km²) State designated and protected Central Pine Barrens region. This remarkably undeveloped region overlies part of Long Island's federally designated Sole Source Aquifer which provides drinking water to nearly three million residents, and it contains terrestrial and aquatic ecosystems of statewide and national significance, interconnected surface and ground waters, recreational areas, historic locales, farmlands, and residential communities.

On March 12, 1791, Massachusetts agreed to sell its reverted pre-emptive right to lands west of the Genesee to Robert Morris for $333,333,33. The land was conveyed to Morris in five deeds on May 11, 1791. At that time, Morris was the richest man in America, as well as a signer of the Declaration of Independence, and a financier of the American Revolution.

The south shore of Lake Ontario provides the right mix of soils and microclimate for many apple, cherry, plum, pear and peach orchards. Apples are also grown in the Hudson Valley and near Lake Champlain. The south shore of Lake Erie and the southern Finger Lakes hillsides have many vineyards. New York State is the nation's third-largest wine-producing state, behind California and Washington State.